Women who have a stillbirth are four times more likely to get Lupus

Women who suffer the tragedy of stillbirth are four times more likely to develop Lupus in later life, study finds

  • Experts analysed the outcomes of more than 100,000 recorded pregnancies
  • They found an association between stillbirths and connective tissue disorders
  • However, the team noted that the correlation with Lupus was the strongest
  • The first detectable signs of Lupus can appear up to five years after the event
  • It is thought that around 1 in 240 women in the United Kingdom suffer a stillbirth

Women who suffer the tragedy of stillbirth four times more likely to develop Lupus in later life than those who experience an uncomplicated birth, a study has found.

Researchers from Manchester found a link between stillbirths and connective tissue disorders — with the association with Lupus being by far the strongest.

Connective tissue disorders affect the tissues that support our organs and other parts of the body.

The team found that the presence of the antibodies that form the first signs of Lupus can appear up to five years after a stillbirth, without accompanying symptoms. 

This, they suggest, indicates that many women may get pregnant without being fully aware of the risks — or lose their baby without knowing the reason why.

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Women who suffer the tragedy of stillbirth four times more likely to develop Lupus in later life than those who experience an uncomplicated birth, a study has found

‘Stillbirth leaves both a psychological and a biological legacy,’ said paper author and obstetrician Hannah Kither of the University of Manchester.

‘This study shows quite conclusively that these women have an increased risk of developing Lupus.’

‘Either the stillbirth is a result of underlying immunological abnormalities akin to that seen in Lupus, or that the stillbirth itself triggers a cascade of immune reactions in the maternal system culminating in connective tissue disorders.’

‘The impact of stillbirth is traumatic — and the worries over having complications later on will be doubly hard for these women. But we hope the knowledge this research gives them will empower them in future years.’

In their study, Dr Kither and colleagues studied the outcomes of more than 100,000 pregnancies, looking to see if those women who had a still birth subsequently developed lupus, connective tissue disease or autoimmune antibodies.

Anonymized patient records were sourced from the Clinical Practice Research Datalink which gathers data from a network of GP surgeries across the UK.

The team used so-called ‘statistical regression’ to compare the outcomes of live- and stillbirths and calculate the relative risk ratios.

‘As stillbirth is now a known risk factor for Lupus, GPs should be aware of this when seeing their patients’ investigation results,’ said Professor Heazell. ‘Women should also be vigilant and look out for symptoms of Lupus which include joint pain, muscle pain and chronic fatigue’

‘When women have a stillbirth they are screened for a range of diseases, but now we know Lupus won’t appear until much later — sometimes years later,’ paper author and obstetrician Alex Heazell, also of the University of Manchester, added.

‘As stillbirth is now a known risk factor for Lupus, GPs should be aware of this when seeing their patients’ investigation results.’

‘Women themselves should also be vigilant and look out for symptoms of Lupus which include joint pain, muscle pain and chronic fatigue.’

‘Around 1 in 240 women in the UK suffer a stillbirth, this affects a lot of women so we feel action is needed.’

‘This study gives a strong steer that pregnant women should be tested early on for lupus and other related diseases, so that doctors can keep a close eye on anyone at risk throughout their pregnancy and beyond,’ said Tommy’s charity CEO Jane Brewin.

‘We know that both lupus and baby loss are more common in BAME communities, but previous investigations of the link between […] have come from countries that aren’t as diverse as the UK, so this study gives us important new insight. ‘

‘That said, it can’t tell us whether connective tissue disorders were the cause or the result of stillbirth — so we need more in-depth research to unpick that relationship, , which is why Tommy’s set up the Manchester LIPS clinic with Sparks.’

The full findings of the study were published in the British Journal of Obstetrics and Gynaecology. 

WHAT IS A STILLBIRTH?

A stillbirth occurs when a baby is born dead after 24 weeks of pregnancy. 

If a baby dies before 24 weeks of pregnancy, it is known as a miscarriage.

Not all stillbirths can be prevented, however, not smoking or drinking, as well as not sleeping on your back and attending all antenatal appointments can reduce the risk. 

What are the signs? 

Signs may include the baby not moving as much as normal.

Pregnant women should contact their doctor immediately if they notice a difference to their baby’s movement. 

What are the causes? 

Stillbirths do not always have an obvious cause but may occur due to complications with the placenta or a birth defect.

They are also more likely to occur if women suffer from high blood pressure, diabetes or an infection that affects the baby, such as flu. 

Stillbirths are more likely to occur if women are having twins or multiple pregnancies, are overweight, smoke, are over 35 or have a pre-existing condition, such as epilepsy.

What happens after a stillbirth? 

If a baby has died, women may wait for their labour to start naturally or they may be induced if their health is at risk. 

Bereavement support groups are available to parents who have suffered stillbirths.

Some find it helpful to name their baby or take pictures with them.  

 Source: NHS Choices

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Alien religion on Mars: Conspiracy theorists claim to find SIGN OF THE CRUCIFIX

The extraordinary claim comes after UFO hunters spotted what they believe is a cross carved into a rock on Mars. Next to the supposed sign of the crucifix is apparently a statue of a lamb.

This is apparently further proof that any aliens on Mars believe in Jesus Christ, as the lamb allegedly represents the lamb of God.

The claim was made by prominent conspiracy theorist Scott C Waring who found the items in images from NASA’s Curiosity Rover.

The alien enthusiast says that these findings are evidence that not only was there once an intelligent species on Mars but that Jesus Christ travelled the cosmos enlightening planetary races.

Mr Waring wrote on his blog ET Database: “The cross is deeply carved into a black of stone.

“The stone clearly didn’t belong here, but was placed here by someone.

“The stone is about six inches high. Right next to it is a statue of a sheep that has fallen on its side which is about eight inches long.

“The statue looks more worn and eroded, but it’s clearly a sheep. I’m not a religious guy and didn’t go out looking for this.

“I just came across the photo and found it. These small statues are further proof that a tiny alien race once existed on Mars.

“Now I believe in the Christian faith that the lamb is sometimes referred to as the lamb of god, or god being kind and caring.

“But it could also mean the followers of the faith, who often refer to themselves as sheep.

“What gets my goat, no pun intended, is that the cross didn’t become a Christian symbol until Jesus died upon it 2,000 years ago on Earth.

“But if Jesus did the same on Mars too, then this is further proof that Jesus was an alien trying to instil morals and ethics onto not just humanity but other intelligent species too.

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“Now the plain cross is supposed to be a symbol of Jesus resurrection. Where a cross with him on it means the sacrifice Jesus made for humanity.

“This seems too much of a coincidence that two religious icons would be sitting so close to one another. This has to be actual religious evidence of an alien culture on Mars.”

However, sceptics and NASA would say the statue and the supposed cross are just the effects of pareidolia – a psychological phenomenon when the brain tricks the eyes into seeing familiar objects or shapes in patterns or textures such as a rock surface.

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Christopher Stevens on A House Through Time and last night's TV

CHRISTOPHER STEVENS reviews last night’s TV: Slavery, a killer pirate… and a treasure chest of twisted history

A House Through Time

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The Yorkshire Vet: The Peter Wright Story

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What a surprise. Of all the houses that Lefty British-Nigerian historian David Olusoga could have picked to illustrate Bristol’s past, he chose one steeped in slavery.

True, it was a big part of the city’s history. But he might have selected 13 Lansdown Place, the home of Victorian doctor William Budd, as the location for his third series of A House Through Time (BBC2). Dr Budd discovered how epidemics of typhoid and cholera were spread, and his work has been crucial in helping us understand Covid-19.

Or, Olusoga could have gone for the site on Clifton’s Triangle where oddball William Friese-Greene worked as a photographer’s apprentice in the 19th century before he invented moving pictures.

Thanks to Friese-Greene, another Bristol lad found fame in the Thirties, changing his name from Archibald Leach to Cary Grant. He was born at 15 Hughenden Road, in Horfield.

The historian David Olusoga (pictured), who has lived in Bristol (my home town) for 20 years, clearly sees the complex past of this city in starkly divisive terms

Instead, Olusoga chose 10 Guinea Street, close to the city docks, which was built on profits from the slave trade 300 years ago and first rented out to a slave-ship captain.

The historian, who has lived in Bristol (my home town) for 20 years, clearly sees the complex past of this city in starkly divisive terms.

For a year or so, the house was occupied by a scribbler named John Shebbeare, a political satirist. He was put on trial for libel after publishing a pamphlet that blamed all Britain’s problems on its German king, George II.

The novelist Fanny Burney once went to dinner with the Shebbeares and reeled away in horror at the man’s crass jokes — sexist and politically incorrect even by Georgian standards. But his outspoken attacks on the corrupt government made him hugely popular with ordinary people.

A Bristolian bigmouth, famous for his rudeness, who probably wasn’t half as funny as he thought he was, Dr Shebbeare might just be my new patron saint.

Another eccentric typical of the town had a fleeting cameo in the Guinea Street story: pirate captain Bridstock Weaver. The way Olusoga told it, Weaver was an unfortunate soul, trapped in a life of crime by no fault of his own, who reformed and settled in Bristol.

His life was supposedly ruined by a slave trader (yes, another one) who happened to be living at No 10. But a look at the National Archives reveals Weaver was nobody’s victim: a murderer, a schemer and a ruthlessly successful robber.

Painting such a colourful villain as a wronged man is ridiculous. That’s what happens when history is twisted to fit a preconceived theory. 

It was gently amusing to see the shudder of fear that crossed Peter Wright’s (pictured) face when he recalled his first telling off from an apoplectic Siegfried — after turning up late for work without his tie

The past was more benign on The Yorkshire Vet: The Peter Wright Story (C5) as the softly spoken animal doctor retraced his life playing apprentice to Alf Wight and Donald Sinclair — better known as James Herriot and Siegfried Farnon in All Creatures Great And Small.

Channel 5 is remaking All Creatures, airing it later this year to coincide with the 50th anniversary of these much-loved books. Samuel West plays Siegfried and Callum Woodhouse, from The Durrells, is his amiably hopeless younger brother, Tristan.

Peter Wright has told many of these stories before, over the five years that documentary cameras have followed him on late-night lambing trips and cattle births across the North Riding.

But it was gently amusing to see the shudder of fear that crossed his face when he recalled his first telling off from an apoplectic Siegfried — after turning up late for work without his tie. Peter’s reason? He’d been up all night, struggling to deliver a calf. That excuse didn’t save him.

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Hoping for a tidy profit? Junk-filled house on Rightmove for £210,000

Hoping for a tidy profit? Junk-filled house strewn with clothes, rubbish, toys and even a bath full of water goes up for sale on Rightmove for £210,000

  • Usually sellers want to make their property look as attractive as possible 
  • But a house is on the market with rooms and garden in a dreadful state 
  • End-of terrace building is up for £210,000 and looks a mess in pictures  
  • There is laundry on the floor, a dirty mattress and junk strewn everywhere 

A property pictured full of junk as been put up for sale on Rightmove for £210,000, breaking every rule in the book for those looking for a buyer. 

Usually those looking to sell their home want to make the rooms glisten and look as enticing as possible but one in Canterbury, Kent, has been put on the market looking completely unkempt. 

The property listed on Rightmove is described as a ‘great first time home, downsize or investment but those interested will have to look past the rubbish in the images. 

A filthy mattress, rubbish and assorted junk are seen in pictures of the property up for sale in Canterbury, Kent with the hoover and carpet cleaner apparently unused

The end-of-terrace building is on the market for £210,000 and has ‘no chain’ involved

A picture of the lounge shows a Christmas tree toppled over with wires across the floor

The end-of-terrace building is up a ‘quiet cul-de-sac’ and the first sign of mess is in the garden outside. 

Junk is piled up on the lawn, a bin has toppled over and an expensive looking children’s toy Mercedes is tilted between the concrete and lawn. 

The kitchen is in a similar state, with clothing across the floor and worktops rammed full of toys and documents. 

A tub of what appears to be paint is on the floor alongside a screwdriver. 

There is a vacuum cleaner and carpet cleaner in the living room but both appear to have gone unused given the condition of the rooms. 

Rubbish is scattered on the floor, a mattress without duvet or pillow cases on is also on the ground and there is the sorry sight of a toppled Christmas tree in front of doors leading to the garden. 

A children’s bedroom is also in the pictures used to advertise the house featuring a wooden cot, tiny metal bed and slightly larger mattress all in one room. 

The bathroom, unlike everywhere else in the property, appears to be clean but bizarrely still has water in the bathtub. 

A children’s bedroom shows a wooden cot, small bed and larger mattress in the room

A snap of the bathroom bizarrely shows water still in the tub, although it looks relatively clean

The home is advertised as ‘chain-free’ and Rightmove’s description states it is: ‘Ideally located for both the city centre and University of Kent.

‘The ground floor accommodation comprises the entrance hallway, kitchen/diner and separate lounge. Upstairs you will find two double bedrooms, both with fitted wardrobes, the family bathroom is brand new and unused and separate WC. 

‘The property benefits from double glazing and central heating throughout. Outside you will find the rear garden which is mainly laid to lawn with a patio seating area.’

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Girl, 3, drowns in a swimming pool ‘after her family got distracted with another child’ during a party at an Airbnb – The Sun

A THREE-year-old girl has died after slipping into a swimming pool while her family was distracted by another child at a gathering over the weekend.

About 12 people got together for the backyard party at an Airbnb home in Arizona on Saturday afternoon when the toddler quietly went underwater, authorities said.

"Multiple children" under the age of 10 were in the backyard, distracting the adults at the party, fire officials told KSAZ.

"Approximately 12 family members including multiple children under the age of 10 were in the back yard when the toddler slipped into the pool unnoticed," the Glendale Fire Department said in a news release Saturday night.

"The family members were reportedly distracted by another child when the toddler slipped into the pool unnoticed."


After some time, the child was taken from the pool and a family member performed CPR on the little girl.

A neighbor, who is a nurse, overhead the commotion and performed CPR until emergency crews arrived, according to the news station.

When crews arrived, the little girl didn't have a pulse and wasn't breathing on her own, the fire department said.

The child died at the hospital hours later, and crisis response teams were at the scene helping the girl's distraught family, KSAZ reported.

The fire department noted there was no pool fence at the home.

"This is a good time to remind people to designate a water watcher when having a gathering," fire officials said.

"Someone who's (sic) entire responsibility is to watch the water. It only takes a few seconds for a child to go under the water undetected."

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Chloe Ferry strips off to a black bikini as she shows off her two-stone weight loss – The Sun

CHLOE Ferry shared another flesh-flashing photo of herself in the bathroom showing off her new streamlined curves.

Taking to Instagram, the reality star peeled off her clothes and posed in a black embellished bikini set.

The 24-year-old wowed with her new toned and trim body transformation.

With her long blonde locks down, she showed off her thigh and underboob tattoo while looking down coyly and wearing a cross necklace with a full face of make-up and lashes.

Fans wrote in the comments that she looked 'stunning', 'gorgeous' and remarked that she was looking 'unbelievable'.

The TV star previously revealed that she’s gone from 11 stone seven pounds, to nine stone nine pounds in just 12 months.

She recently opened up about her changing body, revealing two very different photos of herself taken one year apart.

Chloe wrote: "It has taken a lot for me to upload these photos, as you know I'm judged on anything I do.

"A few years ago if anyone had told me where I’d be today I'd have laughed at them.

"It all started a good few years ago, being put into the spotlight and in the public eye at a very young age.

"Every aspect of my life was commented on – more so than anything else was my appearance.

"I'm a tough person, but waking up every day to comments like: 'You look fat' or 'get a boob job' really start to stick in your head, and it makes you start to think these people are right – I do need a boob job, or I do need to lose weight."

Admitting that she turned to cosmetic operations for a "quick fix", Chloe added: "I wanted a quick fix and turned to surgery thinking all these comments would go over night. This couldn’t have been further from the truth! In fact they increased!

"More fat comments, more about the way I looked. It eventually made me dread posting a photo because of all the trolls out there."

The reality TV favourite then decided to make a "lifestyle choice", switching surgery for the gym and "looking after" her body.

She wrote: "It wasn’t just good for my body, but good for my mind. At this point the negative comments became the driving factor to push me harder.

"Put yourself in my shoes, and imagine opening your Instagram to thousands of comments about being fat. I would not wish this on anyone.

"Now, I’m body confident in my own skin and happy with the way I look, physically and mentally. I’m finally feeling great! If I can do it so can you, and I want to be there to help anyone feeling that they can't."

The reality star recently paid Katie Price an unusual tribute on her 42nd birthday – posting a video showing her grinding on the ex model.

The former Geordie Shore favourite shared a clip from a wild night out with Pricey where she sat on her lap waving her arms and rubbing her bum.

She wrote: "Happy birthday sexy" before tagging her into the video in big letters.

The pair are both seen in the footage playing around for the camera and flicking their hair at what appears to be a club with a DJ in the background.

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Tom Heap wife: Who is the Countryfile presenter’s wife?

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Tom Heap, 54, has been a regular on Countryfile since 2009, which currently airs every Sunday. Tonight’s episode sees the show head to the home patch of Countryfile reporter Sean Fletcher in Hampton Court. The show also takes a look at Kate Humble’s home in Wye Valley, where she will explore how local food producers are adapting amid the crisis.

Tom is one of the main presenters on Countryfile, but he also is the Rural Affair Correspondent for the BBC.

Tom’s career in journalism started with Sky News, where Tom was a sound mixer.

He later joined the BBC through a trainee scheme with BBC News where he worked for the Today programme as well as the BBC News 24 channel and Panorama.

After becoming interested in rural affairs, science and the environment Tom took on a newly created role at the BBC as the Rural Affairs Correspondent which allowed him to specialise in the topic further.

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Is Tom Heap married?

While Tom has become well known for presenting on our screens, he is keen to keep his private life out of the spotlight.

Tom is reported to be married to wife Tammany Robin Stone.

The couple is said to have married in 1992 and have been married for over 25 years.

It is not known whether Tom and Tammany have children together.

However, while Tom was working on the show Slash Your Bills which saw him trying to turn his family’s new home into a paragon of energy efficiency he was asked: “What do Tom’s wife and children think?”

In the past, Tom has spoken on how children should be exposed to the harsh realities of abattoirs in aid of better food education.

In 2018, in a piece he wrote for the Radio Times, Tom wrote: “I honestly believe that slaughterhouses, intensive chicken barns or crowded pig pens should be open to the public eye.

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“Schools should be encouraged to visit as part of the curriculum.”

Tom went on to say: “The public cares about the welfare of the animal and the health of the environment behind the food on their plate.

“Much of the farming industry is nervous about letting the cameras in … for me, secrecy breeds malpractice inside and, frequently unjustified, suspicion on the outside.

“It’s very easy for campaign groups to fill in the void with their own version of how animals are treated.”

In 2012 Tom took over the investigative reporter role on Countryfile from John Craven.

Back in April 2018, Tom showed graphic footage of animals in cramped conditions before watershed as part of his investigative segment of the show.

On the episode, Tom said: “Countryfile – like the countryside – is not a ‘safe space’ and we shouldn’t hide or gloss any uncomfortable truths.”

Countryfile is on BBC One tonight at 7.15pm.

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Kim Jong Un makes appearance at military meeting, state media reports

North Korean dictator Kim Jong Un has emerged in public for the first time since May 1, hosting a military meeting, state media KCNA reported, according to Reuters.

“Set forth at the meeting were new policies for further increasing the nuclear war deterrence of the country and putting the strategic armed forces on a high alert operation,” KCNA said.

Photos show a robust-looking Kim sitting at an oversize desk, a white mug in front of him, presiding over rows of attendees.

The Hermit Kingdom leader’s last appearance — after being rumored to be sick or even dead — was to cut the ribbon for the opening of a fertilizer factory.

There was more speculation this week about Kim’s whereabouts after his supreme commander emblem had been erased from North Korean TV.

Some surmised that Kim may have been merely holing up in his lavish seaside estate .

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BTS: Jin and Jungkook Made a Surprise Cameo in Suga's Music Video for 'Daechwita'

We stan supportive band members. On May 22, Suga released his second mixtape under the persona Agust D, D-2. It’s a blink-and-you-miss-it moment, but in Suga’s new music video for “Daechwita,” the mixtape’s lead single, BTS’s Jin and Jungkook make a surprise cameo.

‘Daechwita’ is the lead single from Suga’s new mixtape

D-2 consists of 10 tracks: “Daechwita,” “Moonlight,” “What do you think?,” “Strange (feat. RM),” “28 (feat. NiiHWA),” “Burn It (feat. MAX),” “People,” “Honsool,” “Interlude : Set me free,” and “Dear my friend (feat. Kim Jong Wan of NELL).”

“Daechwita” serves as the mixtape’s lead single, and Suga released a music video as Agust D for the song. “Daechwita” combines traditional Korean military music and instruments with modern hip-hop beats, and the music video reflects that styling. In the music video, Agust D portrays two different characters. One of historic Korean royalty, and another modern character.

“The first thought I had was that I wanted to sample the music that is played during the ceremonial walk of the King, so naturally, Korean elements ended up being an essential component to the track as well as the music video,” Suga told TIME.

RELATED: BTS: Suga Surprise Drops Second Mixtape ‘D-2’ With Lead Single ‘Daechwita’

BTS fans can’t get enough of Jin and Jungkook’s appearance

To fans’ surprise and amusement, Jin and Jungkook make a cameo in the “Daechwita” music video. A minute into the video, Jin bumps into the dark-haired Agust D character and turns around, inadvertently hitting Jungkook as he walks by. Agust D keeps walking and rapping to the camera, while Jin and Jungkook begin to quarrel in the background.

“Oddly comforting knowing that in every reincarnation jinkook are together and also bickering,” a fan tweeted.

“THEY REALLY CAN’T LET SEOKJIN BREATHE EVEN AFTER A THOUSAND YEARS REINCARNATION LMAO #AGUSTD2 #DAECHWITA,” wrote a Twitter user.

“That bangtan bomb is gonna be funny as h*ll. can’t wait to see jungkook and jin practicing how they were gonna fight and jungkook making fun of jin’s beard,” one fan tweeted.

“Yoongi rapping while jinkook throw hands in the background has to be the best thing I’ve ever witnessed,” another fan tweeted.

There was a countdown leading up to Suga’s mixtape

Before Suga released D-2 as Agust D, there was a special countdown for BTS fans on Twitter. Starting on May 17, Big Hit Entertainment posted a clue every day at midnight KST. Each hint featured a grayscale picture that became clearer every day, as well as a countdown beginning with “D-7.”

By the “D-4” hint, fans knew the countdown was for a BTS member’s solo project, and a large number of BTS fans were convinced the countdown was for another Agust D mixtape. However, most fans assumed the mixtape would drop after the countdown reached “D-1.” Instead, Suga released the mixtape after the “D-2” clue dropped, surprising fans as it came before the technical end of the countdown

RELATED: What Are BTS and Big Hit Entertainment Counting Down To?

In an interview with Billboard, Suga discussed why he released the album earlier than expected.

“I like surprises, so I came up with the release promotion myself. I didn’t want to release it on D-DAY, and also wasn’t satisfied with just Agust D 2. So I wanted to release it on D-2 to surprise the people who were waiting for it to drop on D-DAY,” he said.

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'Scream' Fans Have a Crazy Idea About Where the Next Movie Should Go

Whether fans want it or not, Scream 5 is well on its way. The movie took a major step forward recently with news that David Arquette is officially returning. The actor played Dewey Riley in all four previous Scream movies. Moreover, his casting means one-third of the series’ main trio — which also includes Neve Campbell and Courteney Cox — is now onboard.

But after three sequels — one of which serves as a quasi-reboot — and a TV series, Scream 5 needs a new angle. And some fans think they’ve figured out the best way to set the new movie apart. Better yet, the proposed concept could very well honor the late Wes Craven at the same time.

‘Scream 5’ needs to find a way to honor Wes Craven’s legacy

Scream 5 directors Matt Bettinelli-Olpin and Tyler Gillett have big shoes to fill. After all, Craven directed all four previous films. The duo’s 2019 release, horror-comedy Ready or Not, indicates they have the right idea about how to toy with genre conventions. But taking on a legacy property like Scream requires more than just a deft storytelling hand.

The franchise has been around for decades. And especially after Craven’s death in 2015, any subsequent movie needs to pay tribute to the late director and his work. So far Bettinelli-Olpin and Gillett seem to be on the right track. Kevin Williamson — who wrote three of the four Scream films under Craven — will return for Scream 5 as an executive producer.

But for the fifth entry in a horror franchise, the real trick will be finding a story angle that feels fresh. Certainly, someone in a Ghostface mask will engage in a murderous rampage. Yet, the circumstances surrounding that can’t risk leaving fans of the decades-old series feeling like they’ve seen this before. Thankfully, the dedicated Scream fan base have that covered.

RELATED: ‘Scream 5’: Neve Campbell ‘Negotiating’ a Return; Which Other Stars Could Return?

Fans have come up with the perfect way to bring back the original cast

One common fan theory about where Scream 5 can go is for Campbell’s Sidney Prescott to become the killer. After being the central target of four previous killing sprees, it’s plausible she would crack and grab the Ghostface mask for herself. But screenwriter Brian Lynch recently took to Twitter with an even more tantalizing notion.

Lynch’s idea is for the new film to be set in the real world. So, instead of Campbell, Arquette, and Cox playing their respective roles, they would be playing themselves. Essentially, a “real-life killer” inspired by the Scream movies takes the fate of the franchise into his or her own hands.

As Lynch points out, this opens the door for any of the series’ previous cast members to return, including Drew Barrymore. For most horror series, this idea would be too high-concept to work. But Scream has always prized itself on embracing its own self-awareness. Lynch’s idea would take that notion to the next natural step. Plus, it’s one we know Craven would love.

RELATED: ‘Scream’: 13 Stars You Forgot Appeared in the Beloved Horror Movie Series

Wes Craven took a similar approach with ‘Wes Craven’s New Nightmare’

Without the legendary horror filmmaker around to helm Scream 5, all the series can rely on is the body of work he left behind. And it just so happens that the director applied a very similar premise to his other signature franchise.

In 1994, Craven wrote and directed Wes Craven’s New Nightmare. The seventh and final entry in A Nightmare on Elm Street stars Heather Langenkamp as herself. The actress who played Nancy Thompson in the series battled Freddy Krueger. And she winds up having to make another Elm Street film to stop Freddy from continuing his real-life rampage.

In many respects, Wes Craven’s New Nightmare feels like a spiritual predecessor to the first Scream, which Craven made just two years later. Instead of Freddy, Scream 5 could reveal Ghostface to be Campbell herself, who wants to return to her signature role. Perhaps Cox — arguably the most successful member of the original cast — will even be the opening victim.

In this scenario, Scream 5 would echo the original Scream and allow the meta-focused series to riff on Wes Craven’s New Nightmare. Will this be the story Bettinelli-Olpin and Gillett end up going with? Fans will have to wait and see. But after previous entries commented on horror movies, sequels, trilogies, and reboots, it feels like the perfect way to bring it all full circle.

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